We have been overloaded in the past few years with enormous amounts of information in the form of deciphered genomes, bacterial, plant, humanÉ The sequence of a gene tells us the order of the amino acids in the protein it codes for, but what good does that information do us? Structural biologists take advantage of the physical properties of proteins in various states to uncover the three-dimensional fold, which in turn tells us something about the function of the protein. This directed study will cover some of the basics of these techniques and how these techniques differ in the kind of information they give us. The hands-on part of this directed study will involve learning to purify and crystallize proteins for use in x-ray crystallography.
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