A rapid progression of discovery of new gene function has occurred over the last 10 years due to the advancement of gene manipulation in the mouse. Both the inactivation of genes and over-expression of gene function have lead to discoveries of important new functions. A critical area of importance in the analysis of genetically engineered mutant mice is the accurate phenotyping. Pathologic analysis of the organs from the mice is one method to phenotype the alterations. Students will get the opportunity to examine histologic sections of mice that have undergone genetic manipulation, and discuss the ramifications of the deleted genes. This will offer a diverse view of some of the interesting avenues of gene research and therapy.
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